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Mandelie van der Walt on Muck Rack

Mandelie van der Walt

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Articles

Scorpion venom-derived Opis16a shows potent membrane-destabilising Gram-negative activity and promising in vivo topical efficacy

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By Carel Oosthuizen, A. James Mason, Mandelie van der Walt, Megan J. Bester, Anabella R. M. Gaspar
| Nature Verified
Abstract Antimicrobial peptides (AMPs) are lead candidates for antibacterial drug development, especially against multidrug-resistant Gram-negative bacteria. Previously, we showed that Opis16a, a novel scorpion venom-derived AMP, exhibits broad-spectrum activity against drug-resistant Gram-negative strains with minimal toxicity to mammalian cells. However, its mechanism of action remained unclear.
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