Mandy Brigitte Esch

From animal testing to in vitro systems: advancing standardization in microphysiological systems Limitations with cell cultures and experimental animal-based studies have had the scientific and industrial communities searching for new approaches that can provide reliable human models for applications such as drug development, toxicological assessment, and in vitro pre-clinical evaluation.

Pumpless Microfluidic Devices for Generating Healthy and Diseased Endothelia We have developed a pumpless cell culture platform that can recirculate small amounts of cell culture medium (400 µL) in a unidirectional and bidirectional flow pattern. The device produces an average wall shear stress of up to 0.587 Pa ± 0.006 Pa without the use of a pump.