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Manivel Rengasamy

As seen in: Nature, Cambridge University Press & Assessment, MDPI
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Articles

Effects of ketamine on individual symptoms and symptom networks of depression in a randomised controlled trial of ketamine for treatment-resistant depression | The British Journal of Psychiatry | Cambridge Core

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By Shabnam Hossein, Manivel Rengasamy, Aiyedun Uzamere, Crystal Spotts
| Cambridge University Press & Assessment
In recent years, ketamine has emerged as an effective rapid-acting treatment for depression and treatment-resistant depression (TRD). Reference Ballard, Price, SJ and CA1 Intravenous (i.v.) ketamine treatment seems to have maximal effects approximately 24 h after infusion, with persistence of effects for 1–2 weeks after treatment, and approximately a 40–46% response rate in this timeframe.
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On the pursuit of reproducibility: the importance of large sample sizes in psychoimmunology - Translational Psychiatry

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By Manivel Rengasamy, Daniel P Moriarity
| Nature Verified
Abstract Peripheral inflammatory markers (PIMs), such as C-reactive protein (CRP) or white blood cell count (WBC), have been associated with depression severity in meta-analyses and large cohort studies. However, in typically-sized psychoimmunology studies (N < 200) that explore associations between PIMs and neurobiological/psychosocial constructs related to depression and studies that examine less-studied PIMs (e.g., interferon gamma), significant concerns about reproducibility of results exist.
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