Manjunatha Shivaraju on Muck Rack

Manjunatha Shivaraju

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Articles

Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells

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By Isha Jain Verified, Manjunatha Shivaraju, Udbhav K. Chitta, Diane Capen
| Science Magazine Verified
Protecting the lung from hypoxic stress The lung experiences constantly changing oxygen concentrations and must recognize and respond to a low-oxygen environment. Shivaraju et al. reveal that airway stem cells directly sense hypoxia and respond by differentiating into protective neuroendocrine (NE) cells that secrete a peptide that mitigates tissue damage (see the Perspective by Zacharias).
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