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Mansen Yu

As seen in: Nature
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Articles

The proto-oncogenic miR-106a-363 cluster enhances adverse risk acute myeloid leukemia through mitochondrial activation - Leukemia

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By Mansen Yu, Sarah Grasedieck, Tobias Maetzig, Lars Palmqvist, Sebastian Wiese, Linda Fogelstrand, Arefeh Rouhi, Irina A. Maksakova, Dexter Kim
| Nature Verified
Abstract We investigated the clinical and functional role of the miR-106a-363 cluster in adult acute myeloid leukemia (AML). LAML miRNA-Seq TCGA analyses revealed that high expression of miR-106a-363 cluster members was associated with inferior survival, and miR-106a-5p and miR-20b-5p levels were significantly elevated in patients with adverse risk AML. Overexpression of the miR-106a-363 cluster and its individual members in a murine AML model significantly accelerated leukemogenesis.
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Prevalence of metabolic comorbidities and viral co-infections in monoclonal gammopathy: a retrospective analysis - Leukemia

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By Sabrina L. Browning, Tinatin Muradashvili, Mansen Yu
| Nature Verified
Monoclonal gammopathy (MG) represents a spectrum of related diseases, with monoclonal gammopathy of undetermined significance (MGUS) being the most prevalent. MGUS invariably precedes every case of smoldering multiple myeloma (SMM) and clinical multiple myeloma (MM). A risk of progression from MGUS to MM is about 1% per year [1], whereas for patients with SMM, it can reach up to 63% in 2 years [2].
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