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Manuel Saiselet on Muck Rack

Manuel Saiselet

As seen in: BioRxiv
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Articles

Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancers

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By Adrien Tourneur, Joel Rodrigues Vitoria, Manuel Saiselet, Ligia Craciun
| BioRxiv
Abstract Sixty percent of papillary thyroid cancers (PTCs) are driven by BRAFV600E, a mutation associated with high inter- and intra-tumoral heterogeneity. PTCs may become highly aggressive anaplastic thyroid cancers (ATC). While single cell transcriptomics may resolve this heterogeneity, it is potentially confounded by technical effects whose correction may dampen inter-tumor variations.
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Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells

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By Adrien Tourneur, Ligia Craciun, Joel Rodrigues Vitoria, Manuel Saiselet
| BioRxiv
Abstract Sixty percent of papillary thyroid cancers (PTCs) are driven by BRAFV600E, a mutation associated with high inter- and intra-tumoral heterogeneity. PTCs may become highly aggressive anaplastic thyroid cancers (ATC). While single cell transcriptomics may resolve this heterogeneity, it is potentially confounded by batch effects whose correction may dampen inter-tumor variations.
Open in Who Shared Issue with article?
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