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Articles by Manuela Neumann
Intrathecal nivolumab in metastatic solid tumors with leptomeningeal disease: dose escalation part of the multicenter IT-PD1/NOA-26 phase 1 trial
Abstract Leptomeningeal metastatic disease (LMD) of solid tumors represents a cancer stage with high unmet therapeutic need. Here we report results from the dose escalation part of a multicenter phase 1 trial investigating intraventricular nivolumab, now continuing in the expansion part. Eligible participants had LMD from tumors with an approval for intraveneous PD1/PDL1 therapy or high tumor mutational burden.
Continental-scale associations of Arabidopsis thaliana phyllosphere members with host genotype and drought - Nature Microbiology
Abstract Plants are colonized by distinct pathogenic and commensal microbiomes across different regions of the globe, but the factors driving their geographic variation are largely unknown. Here, using 16S ribosomal DNA and shotgun sequencing, we characterized the associations of the Arabidopsis thaliana leaf microbiome with host genetics and climate variables from 267 populations in the species’ native range across Europe.
Reply to: Re-evaluating evidence for adaptive mutation rate variation - Nature
replying to L. Wang et al. Nature https://doi.org/10.1038/s41586-023-06314-y (2023) Wang and colleagues1 argue that our report2 of lower mutation rates in gene bodies, essential genes and regions marked by H3K4me1 must result from DNA sequencing errors. We appreciate the issues raised by them and by other colleagues3.
Author Correction: Mutation bias reflects natural selection in Arabidopsis thaliana - Nature
Correction to: Nature https://doi.org/10.1038/s41586-021-04269-6 Published online 12 January 2022 The second sentence in the Methods section “Identification of de novo somatic mutations in a resequencing dataset of A.
Psychotic symptoms in frontotemporal dementia with TDP‐43 tend to be associated with type B pathology
INTRODUCTION Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome characterised by progressive abnormalities of personality, behaviour and/or language with relative preservation of memory. FTD is the second most common type of early-onset dementia and is most commonly caused by frontotemporal lobar degeneration (FTLD), a heterogeneous group of pathologies that result in prominent atrophy of the frontal and temporal lobes [1].
Mutation bias reflects natural selection in Arabidopsis thaliana - Nature
Identification of de novo mutations in A. thaliana Col-0 mutation accumulation lines Our training set of mutations was identified from 107 mutation accumulation lines of the A. thaliana Col-0 accession, which is the basis of the A. thaliana TAIR10 reference genome sequence12.
Corona: Impf-Frust in den Hausarztpraxen
Seit die Hausärzte mitimpfen, steigt die Zahl der verabreichten Dosen stark. Doch nach anfänglicher Freude über diesen Erfolg stellt sich in den Praxen der Frust ein. Auf Freude folgt Frust: Lieferengpässe dämpfen die Zuversicht bei Hausärzten. Quelle: imago Wir haben in viele glückliche Gesichter geschaut, Holger Fischer, Hausärzteverband Sachsen-Anhalt erinnert sich Holger Fischer, Hausarzt in Magdeburg und Vorstandsmitglied des Hausärzteverbandes Sachsen-Anhalt.
Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes
Abstract Aggregation of hyperphosphorylated TDP-43 is the hallmark pathological feature of the most common molecular form of frontotemporal lobar degeneration (FTLD–TDP) and in the vast majority of cases with amyotrophic lateral sclerosis (ALS–TDP). However, most of the specific phosphorylation sites remain to be determined, and their relevance regarding pathogenicity and clinical and pathological phenotypic diversity in FTLD–TDP and ALS–TDP remains to be identified.
Neuropathology of non‐tau frontotemporal lobar degeneration
Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome associated with frontotemporal lobar degeneration (FTLD) as a relatively consistent neuropathological hallmark feature. However, the discoveries in the past decade of many of the relevant pathological proteins aggregating in human FTD brains in addition to several new FTD causing gene mutations underlined that FTD is a diverse condition on the neuropathological and genetic basis.
Neuropathology of non‐tau frontotemporal lobar degeneration
Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome associated with frontotemporal lobar degeneration (FTLD) as a relatively consistent neuropathological hallmark feature. However, the discoveries in the past decade of many of the relevant pathological proteins aggregating in human FTD brains in addition to several new FTD causing gene mutations underlined that FTD is a diverse condition on the neuropathological and genetic basis.
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