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Detlef Weigel on Muck Rack

Detlef Weigel

Tübingen
As seen in: Nature, PNAS, Genome Biology, Science Magazine, BioRxiv, Cell Press, eLife, Business People
My handle says it all — not following anymore what happens here.
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Articles

A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism - Nature Genetics

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By Hai-Jun Liu, Haim Ashkenazy, Joffrey Fitz, Christian Kubica, Almudena Morales, Vitaly Voloshin, Victor Llaca, Ilka Reichardt, Pádraic J. Flood, Angela M. Hancock, Ya-Long Guo, Detlef Weigel
| Nature Verified
Abstract Making sense of whole-genome polymorphism data is challenging, but it is essential for overcoming the biases in SNP data. Here we analyze 27 genomes of Arabidopsis thaliana to illustrate these issues. Genome size variation is mostly due to tandem repeat regions that are difficult to assemble. However, while the rest of the genome varies little in length, it is full of structural variants, mostly due to transposon insertions.
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Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals - Genome Biology

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By Andrea Movilli, Svitlana Sushko, Fernando A. Rabanal, Detlef Weigel
| Genome Biology Verified
To investigate the extent to which TEs mobilize somatically in A. thaliana, we made use of met1 mutants, which are known to have increased TE activity [14]. First, we de novo assembled the genome of the non-reference accession Tsu-0 (1001 Genomes Project ID: 7373) with PacBio HiFi reads, followed by annotation of protein-coding genes and TEs (Additional file 1: Table S1a,b, Fig. S1a,b, S2a-d).
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Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals

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By Andrea Movilli, Fernando A. Rabanal, Detlef Weigel, Svitlana Sushko
| BioRxiv
Abstract Because transposable elements (TEs) can cause heritable genetic changes, past work on TE mobility in Arabidopsis thaliana has mostly focused on new TE insertions in the germline of hypomethylated plants. It is, however, well-known that TEs can also be active in the soma, although the high-confidence detection of somatic events has been challenging. Here, we leveraged the high accuracy of PacBio HiFi long reads to evaluate the somatic mobility of TEs in individuals of an A.
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