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Articles by Maolin Li
Functionalized GelMA-based hydrogels for osteoimmunomodulation and bone regeneration
Abstract Complex bone defects caused by trauma, infection, tumor-related bone loss and metabolic disorders remain clinically challenging because an inflammatory imbalance, impaired vascularization and insufficient osteogenesis often coexist. Gelatin methacryloyl (GelMA) hydrogels are attractive matrices for bone regeneration owing to the extracellular matrix-mimicking structure, tunable physicochemical properties and compatibility with injectable, printable and composite systems.
Correction to “pH-Driven Self-Assembly of Functional Lysozyme–Hyaluronan Complex Colloidal Nanoparticles for the Oral Delivery of Lutein” Click to copy article link Article link copied!
The authors note some errors in the Figure 6b in their previously published article. Specifically, the NCM460 cell live/dead staining image for the Control group was incorrected labeled as the Lut (1.46 μg/mL) treatment group. Additionally, the NCM460 cell live/dead staining image for the other Lut treatment group and the Lut@LYS-HANPs (200 μg/mL) treatment group were erroneously merged during figure assembly. The complete Figure 6, with panel b corrected, is presented below.
Harnessing photoenzymatic reactions for unnatural biosynthesis in microorganisms - Nature Catalysis
Abstract Photobiocatalysis provides a powerful strategy for integrating light and biological catalysts to drive abiological transformations. However, its scalability is hindered by high enzyme loading, reliance on costly cofactors and instability under radical-generating conditions. Here we report the integration of light-driven enzymatic reactions into the cellular metabolism of Escherichia coli, bridging flavin-based photobiocatalysis with biosynthesis.
Association between the insulin resistance indices and incident type 2 diabetes across different body mass index states: a cohort study and external validation from two East Asian populations
Keywords Insulin resistance Triglyceride-glucose index Type 2 diabetes mellitus Body-mass index Cohort study East-Asian population Abbreviations ALT (alanine aminotransferase) AST (aspartate aminotransferase) AUC (area under the curve) BMI (body-mass index) BUN (blood urea nitrogen) CI (confidence interval) DBP (diastolic blood pressure) FPG (fasting plasma glucose) HDL-C (high-density lipoprotein cholesterol) HR (hazard ratio) IR (insulin resistance) LDL-C (low-density lipoprotein...
Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring | Translational Psychiatry
Abstract Gestational diabetes mellitus (GDM) and prenatal exposure to valproic acid (VPA) are both constitute risk factors for autism in progeny. Notably, dysmyelination in the corpus callosum serves as a prominent element connecting GDM and autism in the white matter lesions. The cumulative effects of GDM and prenatal VPA on both autistic behavior and dysmyelination in progeny have been investigated in this study.
Dual‐Targeted Biomimetic Hybrid Nanovesicles for Tumor Microenvironment Reprogramming and Intratumoral Bacteria Eradication in Triple‐Negative Breast Cancer
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm70906-sup-0001-SuppMat.docx19.3 MB Supporting Information References 1, , , , , , , , , , Clin. Cancer Res. 2007, 13, 4429. 2, , , , , Nat. Rev. Clin. Oncol. 2016, 13, 674. 3, , , , , , , J. Am. Chem. Soc. 2020, 142, 2699. 4, , , , , , , , , , , , Small 2024, 20, 2309583. 5, Lancet Oncol. 2015, 16, 113. 6, , , , , , , , Carbohydr. Polym. 2019, 225, 115206. 7, , , , , , , , , Small 2023, 19, 2301402.
Photoenzymatic stereoablative enantioconvergence of γ-chiral oximes via hydrogen atom transfer - Nature Catalysis
Abstract Producing enantioenriched molecules from racemic mixtures is essential for manufacturing. Traditional methods such as resolution, deracemization and enantioconvergent catalysis primarily involve separating or converting enantiomers without altering their structures, or functionalization of stereocentres at or proximal to functional groups.
Iridium-free high-entropy Ruthenium-based oxides with activated lattice oxygen towards high efficient and durable acidic water oxidation
Iridium-free high-entropy Ruthenium-based oxides with activated lattice oxygen towards high efficient and durable acidic water oxidation Ruthenium-based oxides are promising high-activity acidic OER catalysts to replace IrO₂ but suffer from poor stability. Here, we report an Ir-free high-entropy (RuCrMnFeNi)O2 electrocatalyst with exceptional activity (212 mV@10 mA cm⁻²) and stability (100 h) in 0.5 M H₂SO₄. In PEM electrolyzers, it operates stably for 300 h at 200 mA cm⁻².
The colloidal stability of natural allophane in alkaline aqueous environment containing different oxyanions
Abstract The specific interaction of monovalent oxyanions (KH2PO4 and KH2AsO4) to positively charged natural allophane reduces the colloidal stability of allophane at pH 5. The colloidal stability can be well predicted by the Derjaguin-Landau and Verwey-Overbeek (DLVO) theory with surface charge density. So, far, research at alkaline conditions, where the oxyanions become divalent and the allophane is negatively charged, is lacking.
An optimization method of high-speed train rescheduling based on PER-D3QN
Advanced search Transportation Letters The International Journal of Transportation Research Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/19427867.2025.2496860?needAccess=true ABSTRACT This paper addresses delay problems from moderate and slight disturbances in high-speed train operation by constructing an optimization model that minimizes total train delay time, solved...
Dual Cascade‐Responsive Multifunctional Nanoparticles to Overcome Bacterium‐Induced Drug Inactivation and Enhanced Photodynamic and Chemo‐Immunotherapy of Pancreatic Cancer
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202412707-sup-0001-SuppMat.docx15.1 MB Supporting Information References 1, , , , , , , , J. Am. Chem. Soc. 2020, 142, 4944. 2, , , , , , , , , , , Nat. Rev. Dis. Primers 2016, 2, 16022. 3, , , , , , Angew. Chem., Int. Ed. 2020, 59, 3028. 4, , , , , , , , , , , , , Angew. Chem., Int. Ed. 2024, 63, 202318485. 5, , , , , , Clin. Cancer Res. 2012, 18, 4266. 6, , , , , , Cell Death Dis. 2024, 15, 131.
Uncovering the role of the Cr dopant in RuO2 in highly efficient acid water oxidation
Uncovering the role of the Cr dopant in RuO2 in highly efficient acid water oxidation† The design of acidic oxygen evolution reaction (OER) electrocatalysts with high activity and durability is the key to achieving efficient hydrogen production. Herein, we report a Cr-doped RuO2 (Ru0.9Cr0.1O2) catalyst that exhibits good OER activity in acidic electrolytes.
Mineralogy of Deep-Sea Manganese Nodules and Advances in Extraction Technology of Valuable Elements from Manganese Nodules
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Study on the Dynamic Evolution of Mining-Induced Stress and Displacement in the Floor Coal-Rock Induced by Protective Layer Mining
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Study on the Driving Factors of the Spatiotemporal Pattern in Forest Lightning Fires and 3D Fire Simulation Based on Cellular Automata
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Low‐Temperature Flexibility of Chiral Organic Crystals with Highly Efficient Second‐Harmonic Generation
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Mechanism of solvent-mediated polymorphic transformation to prepare axitinib form XLI controlled by water activity
Mechanism of solvent-mediated polymorphic transformation to prepare axitinib form XLI controlled by water activity Axitinib (AXI) is widely used in the treatment of renal cancer. Due to its molecule structure containing multiple hydrogen bond acceptors and donors, AXI has been reported five solvent-free polymorphs and over 60 solvates. Among these, form XLI is utilized in clinical treatments due to its stability and efficacy.
Asymmetric photoenzymatic incorporation of fluorinated motifs into olefins
Editor’s summary Carbon-fluorine bonds are notoriously scarce within naturally occurring biomolecules. Li et al. developed an enzymatic approach in which trifluoroiodoethane serves as a fluoroalkyl donor through radical addition to a vinyl arene. The enzyme uses a flavin cofactor as a chromophore, and the active site provides stereocontrol over hydrogen atom transfer to the radical intermediate.
Volume‐Metallization 3D‐Printed Polymer Composites
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202403088-sup-0001-SuppMat.pdf24.3 MB Supporting Information adma202403088-sup-0002-MovieS1.mp421.2 MB Supplemental Movie 1 adma202403088-sup-0003-MovieS2.mp411.4 MB Supplemental Movie 1 adma202403088-sup-0004-MovieS3.mp49.5 MB Supplemental Movie 1 References 1a) , , , , , , , Adv. Eng. Mater. 2023, 25, 2301074; b) , , , , , , , , , , , , , , , Adv. Mater.
Remote Sensing | Free Full-Text | Research on the Carbon Sequestration Capacity of Forest Ecological Network Topological Features and Network Optimization Based on Modification Recognition in the Yellow River Basin Mining Area: A Case Study of Jincheng Ci
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides - Nature Chemistry
Abstract Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational modification chemistries. However, RiPPs are rarely reported as hybrid molecules incorporating biosynthetic machinery from other natural product families.
The Effect of Lysozyme on the Aggregation and Charging of Oxidized Carbon Nanohorn (CNHox) in Aqueous Solution
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Photoenzymatic Asymmetric Hydroamination for Chiral Alkyl Amine Synthesis
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, 146, 15 Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Photoenzymatic Asymmetric Hydroamination for Chiral Alkyl Amine Synthesis
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
pH-Driven Self-Assembly of Functional Lysozyme-Hyaluronan Complex Colloidal Nanoparticles for the Oral Delivery of Lutein
Download Hi-Res ImageDownload to MS-PowerPointCite This:Crystal Growth & Design 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Floatability of Fluorite and Calcite Inhibited by Sodium Hexametaphosphate via Ultrasonic Activation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Remote stereocontrol with azaarenes via enzymatic hydrogen atom transfer - Nature Chemistry
Abstract Strategies for achieving asymmetric catalysis with azaarenes have traditionally fallen short of accomplishing remote stereocontrol, which would greatly enhance accessibility to distinct azaarenes with remote chiral centres. The primary obstacle to achieving superior enantioselectivity for remote stereocontrol has been the inherent rigidity of the azaarene ring structure.
Production of Functional Spherical Particles with Porous Hollow Structures in Water via Oiling-Out Directional Agglomeration
Production of Functional Spherical Particles with Porous Hollow Structures in Water via Oiling-Out Directional Agglomeration Porous hollow spherical particles benefit from special structural features and fascinating physicochemical properties resulting in widespread application. Particularly in pharmaceutical engineering, they have significant advantages for direct compression and drug combination.
Study on Combined Sewer Overflow (CSO) Pollution and Its Control Method Based on Sewage Interception Along Rivers
E3S Web of Conferences 406, 03032 (2023) Study on Combined Sewer Overflow (CSO) Pollution and Its Control Method Based on Sewage Interception Along Rivers 1,2*, 1,2, 3, 1,2, 1,2, 1,2 and 1,2 1 PowerChina Huadong Engineering Corporation Limited, Hangzhou 311122, P.R.China 2 Huadong Eco-environmental Engineering Research Institute of Zhejiang Province, Hangzhou 311122, P.R.China 3 Yangtze Ecology and Environment Co. Ltd., Wuhan 430062, P.R.China * Corresponding author: zhang_bh@hdec.com...
Spot Detection for Laser Sensors Based on Annular Convolution Filtering
Abstract : Spot detection has attracted continuous attention for laser sensors with applications in communication, measurement, etc. The existing methods often directly perform binarization processing on the original spot image. They suffer from the interference of the background light. To reduce this kind of interference, we propose a novel method called annular convolution filtering (ACF).
Structural origins of two-dimensional elastic bending in a nonaromatic organic molecular crystal
Structural origins of two-dimensional elastic bending in a nonaromatic organic molecular crystal† Jiawei Lin,‡a Yuechao Cao,‡a Yanbo Liu,a Maolin Li,a Yifu Chen, a Jianmin Zhou,a Songgu Wu *a and Junbo Gong *ab Abstract Mechanically flexible crystals are generally obtained based on weak interactions in the aromatic systems. Here, we reported the remarkable 2D elastic bending behaviors in a nonaromatic organic molecular crystal.
Solubility Measurement and Data Correlation of Clopidogrel Hydrogen Sulfate (Form I) in Four Binary Solvents Systems at Temperature from 278.15 to 318.15 K
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Chem. Eng. Data 2020, XXXX, XXX Learn More about expanded access to ACS Publications research.
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