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Maolu Yin

As seen in: Science Magazine, BioRxiv
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Articles

A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing

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By Meryem B. Baghdadi, Chloe Lopez-Lee, Madeline R. Luth, Ge Zheng, Maolu Yin, Stuti Mehta, I-Te Chu, Altantsetseg Buyanbat, Qian Zhu, Stuart H. Orkin, Stacy Wang, Alia AlShaye, Kirstin Drainville, Frédérique Bienfait, Karin Tenglin
| Science Magazine Verified
Editor’s summary BCL11A is a transcription factor involved in the development of the brain and hematopoietic (blood) cells. BCL11A plays a major role in the fetal-to-adult hemoglobin switch in red blood cells, and gene therapies targeting BCL11A have shown promise for treating inherited hemoglobinopathies such as sickle cell disease and beta-thalassemia. However, the complexity of gene therapy approaches may preclude accessibility to those individuals in low-and middle-income countries.
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Structural Insights into the DNA-Binding Mechanism of BCL11A: The Integral Role of ZnF6

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By Thibault Viennet, Maolu Yin, Abhilash Jayaraj, Woojin Kim
| BioRxiv
Abstract The transcription factor BCL11A is a critical regulator of the switch from fetal hemoglobin (HbF: α2γ2) to adult hemoglobin (HbA: α2β2) during development. BCL11A binds at a cognate recognition site (TGACCA) in the γ-globin gene promoter and represses its expression. DNA-binding is mediated by a triple zinc finger domain, designated ZnF456.
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By Liang Liu, Xueyan Li, Jiuyu Wang, Peng R. Chen, Maolu Yin, Jiazhi Li
| secure.jbs.elsevierhealth.com
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