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Mara KM Whitford on Muck Rack

Mara KM Whitford

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Articles

Apoptotic cell clearance triggers epithelial fate reprogramming during prostate regression

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By Adda-Lee Graham-Paquin, Deepak Saini, Sophie Viala, Mathieu Tremblay, William A. Pastor, Maxime Bouchard, Luke Martin McCaffrey, Mara KM Whitford
| Nature Verified
Abstract Androgen deprivation induces extensive tissue remodelling in the prostate, characterized by epithelial cell attrition and acquisition of a progenitor-like state in residual luminal epithelial cells. The mechanisms driving differentiated epithelial cells toward a progenitor fate remain unclear. Here, we identify that prostate regression is mediated by the engulfment of apoptotic neighbours by epithelial cells and that efferocytosis promotes acquisition of a progenitor-like state.
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