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SETD2 is a histone methyltransferase and is the only enzyme known to be capable of trimethylation of histone 3 lysine 36 (H3K36me2 → H3K36me3). SETD2 can also methylate non-histone proteins and is important in transcriptional regulation, RNA splicing, DNA damage repair and B cell development and differentiation [1, 2].
Molecular and Cellular Biology / Genetics Mara Mandelia, Kostas Drosopoulos and Spiros Linardopoulos DOI: 10.1158/1538-7445.AM2020-3530 Published August 2020 Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA Abstract Chromosomal instability (CIN) is a form of genomic instability that refers to a dynamic state in which the cells are constantly changing the number and/or the structure of their chromosomes.
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