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Marazuela-Duque A

As seen in: Oxford University Press (OUP)
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SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex

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By Cancer Epigenetics, Proteomic Unit, de la Torre, Marazuela-Duque A
| Oxford University Press (OUP)
Abstract The Sirtuin family of NAD+-dependent enzymes plays an important role in maintaining genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them, SIRT1, is intriguing as it seems to have a general regulatory role in the DNA damage response (DDR) that has not yet been addressed.
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