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Editor’s summary Signaling mediated by growth factors of the FGF family and their receptors Fgfr1 and Fgfr2 contributes to liver repair and regeneration by promoting the detoxification of hepatocyte-damaging compounds. Slabber et al. identified a role for the ubiquitin ligase Uhrf2 in FGFR-dependent hepatoprotection. Partial hepatectomy increased the expression of Uhrf2 in the liver in a manner that required Fgfr1 and Fgfr2.
Highlights • Primary epithelial cells missegregate chromosomes when cultured as monolayers • Organoid culture rescues mitotic defects in an integrin-dependent manner • Tissue architecture promotes correction of merotelic kinetochore attachments • Disruption of tissue architecture could underlie chromosome instability in cancer Summary Much of our understanding of chromosome segregation is based on cell culture systems.
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