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Marc Barritault

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Articles

New Observations on a Low-Grade Diffusely Infiltrative Tumour, SMARCB1 Mutant, Arguing for a New Tumour Type

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By Alice Métais, Giorgia Antonia Simboli, Marc Barritault
| Wiley Online Library Verified
Recent studies have reported very rare, low-grade, diffusely infiltrative tumours (LGDIT), SMARCB1-mutant, expanding the spectrum of central nervous system (CNS) SMARCB1-deficient tumours [1-3]. Despite their indolent clinical behaviour compared with aggressive atypical teratoid and rhabdoid tumours (ATRTs), malignant transformation of LGDIT into ATRT has been described and both share a similar DNA-methylation profile, particularly close to the ATRT-MYC subgroup [1, 4].
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