Marc-Henri Stern on Muck Rack

Marc-Henri Stern

As seen in: Nature, JAMA Network
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Articles

Prevalence of the Predisposing Gene MBD4 for Uveal Melanoma

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By Anaïs Le Ven, Marie-Charlotte Villy, Alexandre Houy, Alexandre Matet, Denis Malaise, Amal Omar, Dominique Stoppa-Lyonnet, Nathalie Cassoux, Manuel Jorge Rodrigues, Lisa Golmard, Marc-Henri Stern, Chrystelle Colas, Marine Le Mentec, Catherine Dubois d’Enghien, Virginie Bubien, Alain Lortholary
| JAMA Network Verified
Prevalence of the Predisposing Gene MBD4 for Uveal Melanoma
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GWAS meta-analysis provides new insights into uveal melanoma risk

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By Huanwei Wang, Jane Palmer, Kari Hemminki, Colleen Cebulla, Aaron Beasley, Nikolaos E. Bechrakis, Antonia L. Pritchard, Karin Wadt, Peter Johansson, Lenha Mobuchon, Samantha Barlow, Kelly Brooks, Timothy Beckman, Catherine M Olsen, Sunil Warrier, Helen Kalirai, Nathan Ingold, Asta Försti, Timothy Isaacs, William J. Glasson, Gayle Williamson, Lindsay McGrath, Vikas Chadha, Elin Gray, Kevin Brown, Paul Camilleri Cauchi, Hauke Thomsen, Julie Connolly, Stuart Macgregor, David Whiteman, Marc-Henri Stern, Sarah E. Coupland, Mohamed Abdel-Rahman, Nick Hayward, Matthew Law, Matthew D’Mellow, Colette Mustard, G. J. M. Shanika R. Jayasinghe, Ngoc-Quynh Le, Jens F. Kiilgaard, Michael Zeschnigk
| Nature Verified
Abstract The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. Five novel UM genome-wide association studies (GWAS) were performed and included for meta-analysis with four previously published UM GWAS. A fixed-effects inverse-variance weighted (IVW) meta-analysis was performed by combining data from these nine UM case-control cohorts.
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Prospective assessment of circulating tumor DNA in patients with metastatic uveal melanoma treated with tebentafusp - Nature Communications

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By Manuel Jorge Rodrigues, Alexandre Houy, Vincent Servois, Gaelle Pierron, Anne Vincent-Salomon, François-Clément Bidard, Marc-Henri Stern
| Nature Verified
Abstract Tebentafusp, a bispecific immune therapy, is the only drug that demonstrated an overall survival benefit in patients with metastatic uveal melanoma (MUM). Circulating tumor DNA (ctDNA) has emerged as a potential prognostic and predictive marker in the phase 3 IMCgp100-202 trial using multiplex PCR-based next-generation sequencing (NGS). In this study (NCT02866149), ctDNA dynamics were assessed using droplet digital PCR (ddPCR) in 69 MUM patients undergoing tebentafusp treatment.
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