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Marcela de Barros on Muck Rack

Marcela de Barros

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Mass spectrometry methods and mathematical PK/PD model for decision tree-guided covalent drug development - Nature Communications

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By Brandon Miller, Jaime Schneider, Jared Auclair, Carla Mattos, Roman Manetsch, Marcela de Barros
| Nature Verified
Abstract Covalent drug discovery efforts are growing rapidly but have major unaddressed limitations. These include high false positive rates during hit-to-lead identification; the inherent uncoupling of covalent drug concentration and effect [i.e., uncoupling of pharmacokinetics (PK) and pharmacodynamics (PD)]; and a lack of bioanalytical and modeling methods for determining PK and PD parameters. We present a covalent drug discovery workflow that addresses these limitations.
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