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Marcia H. Borges on Muck Rack

Marcia H. Borges

As seen in: Frontiers, BioRxiv
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Articles

ω-Phonetoxins inhibit voltage-gated calcium CaV2.2 ion channel splice isoforms of dorsal root ganglia

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By Marcus Gomez, Marcia H. Borges, Diane Lipscombe, Celio Castro-Junior
| BioRxiv
Abstract Cell-specific alternative splicing of Cacna1b pre-mRNA generates functionally distinct voltage-gated CaV2.2 channels. CaV2.2 channels mediate the release of glutamate from nociceptor termini in the dorsal horn spinal cord and they are implicated in chronic pain. One alternatively spliced exon in Cacna1b, e37a, is highly expressed in dorsal root ganglia, relative to other regions of the nervous system, and it is particularly important in inflammatory hyperalgesia.
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Venomics of the milos viper (Macrovipera schweizeri) unveils patterns of venom composition and exochemistry across blunt-nosed viper venoms

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By Joshua S Rest, Isadora S. Oliveira, Marcia H. Borges
| Frontiers
1 Introduction Snake venoms are complex cocktails of bioactive compounds (Calvete, 2013; Casewell et al., 2013), able to disrupt the physiological processes of the envenomated target (Fry et al., 2009).
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