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Marcin D. Roganowicz on Muck Rack

Marcin D. Roganowicz

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Articles

Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids

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By Marcin D. Roganowicz, Devin Christensen, Katarzyna A. Skorupka, Yueping Wan
| Science Magazine Verified
Abstract TRIM5α is a restriction factor that senses incoming retrovirus cores through an unprecedented mechanism of nonself recognition. TRIM5α assembles a hexagonal lattice that avidly binds the capsid shell, which surrounds and protects the virus core. The extent to which the TRIM lattice can cover the capsid and how TRIM5α directly contacts the capsid surface have not been established.
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By Jessica J. Chiang, Banumathi Sankaran, Jacint G. Sanchez, Steven L. Alam, Michael Chi, Marcin D. Roganowicz, Michaela U. Gack, Owen Pornillos
| secure.jbs.elsevierhealth.com
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