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Marco Gambarotti

As seen in: Nature, MDPI
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Articles

Circulating IGF2BP3 enables risk stratification and predicts treatment response in Ewing sarcoma

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By Caterina Mancarella, Alessandra De Feo, Margherita Maioli, Maria Cristina Manara, Cristina Ferrari, Federica Miriam Costantino, Marilena Cesari, Alberto Bazzocchi, Toni Ibrahim, Giuseppe Bianchi Verified, Marco Gambarotti, Katia Scotlandi, Irene Dirignani, Elisa Simonetti
| Nature Verified
Abstract Ewing sarcoma (EWS), the second most common pediatric bone tumor, presents with a markedly heterogeneous clinical spectrum and optimal risk stratification is therefore crucial for improving treatment outcomes. The RNA-binding protein IGF2BP3 is a critical oncogenic driver of EWS malignancy. This study evaluates the clinical utility of circulating IGF2BP3 as a biomarker to predict treatment response and risk of disease progression in patients with EWS.
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Histopathologic Diagnostic Agreement Study in Bone and Soft Tissue Tumors: The SELNET Sarcoma Network Experience

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By Alberto Righi, Marco Gambarotti
| mtr.cool
ORIGINAL REPORTS Introduction Accurate diagnosis is essential to ensure appropriate management of patients with sarcoma, especially in the context of new targeted therapies.1 Diagnosing mesenchymal tumors through histologic analysis presents significant challenges for pathologists. The main obstacles are the limited material available in the case of biopsies, the rarity of mesenchymal tumors, their morphologic heterogeneity, and the existence of several mimics.
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Cancers | Free Full-Text | Conventional Spinal Chordomas: Investigation of SMARCB1/INI1 Protein Expression, Genetic Alterations in SMARCB1 Gene, and Clinicopathological Features in 89 Patients

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By Margherita Maioli, Marco Gambarotti, Stefania Benini, Stefania Cocchi
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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