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Articles by Marcus Renner
Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor
Abstract Desmoplastic small round cell tumor (DSRCT) is an ultra-rare sarcoma with limited treatment options. Here, we show that comprehensive molecular profiling informs diagnosis and individualized therapy in this disease. We report the results of whole-genome/exome, transcriptome, and DNA methylome analyses performed in 30 refractory DSRCT patients, complemented by (phospho)proteomic profiling in nine, within a nationwide precision oncology program.
Diabetes and Metabolism Peer Reviewed Open Access Journals
Journal h-index : 44 Journal CiteScore: 23.62 Journal Impact Factor: 12.50 Average acceptance to publication time (5-7 days) Average article processing time (30-45 days) Less than 5 volumes 30 days 8 - 9 volumes 40 days 10 and more volumes 45 days Research Gate Journal Impact : 0.32 Index Copernicus Value: 83.65 The Journal of Diabetes & Metabolism is an open access, peer-reviewed scientific journal dedicated to publishing significant research across all fields of diabetes, including Type 1...
The 110 reimagined: Toward many more Arroyofests Original
On June 15, 2003, 5,000 people bicycled, walked, skateboarded and pushed their baby carriages on the Historic Arroyo Seco Parkway (aka 110 Freeway) from Pasadena to Avenue 26 near Downtown Los Angeles in a magical and unprecedented event. Many who biked or walked on the freeway that day still have vivid memories of the experience. Twenty years later, this Oct. 29, more than 50,000 people participated in a second ArroyoFest.
Walking and biking on the Pasadena Freeway Original
Twenty years ago, more than 5,000 people seized the opportunity to spend a Sunday morning on the Pasadena (110) Freeway. These people were not in their cars but were riding bikes, walking dogs, pushing baby strollers and skateboarding. A few did cartwheels. They came to the Arroyo Parkway as part of ArroyoFest, a visionary celebration of what a different type of transportation and more livable Los Angeles might look like. Now, 20 years later, a new generation will be able on Oct.
Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma
A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarcinoma (CCA) has been conflicting. We employed a cohort comprising 308 Western-world, non-liver fluke-associated CCAs (159 intrahepatic, 106 perihilar, and 43 distal).
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