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Fractional exhaled nitric oxide (FeNO) is an established marker of type-2 airway inflammation valuable in asthma management [1]. However, non-inflammatory factors, such as changes in airway calibre, may also influence FeNO levels. Airway narrowing reduces FeNO levels, likely due to reduced epithelial surface area limiting the NO diffusion from the airway lining into the lumen [2].
Phenotyping asthma according to the airway inflammatory profile has brought major advance in asthma management over the last 20 years and classifying asthma into eosinophilic and non eosinophilic asthma based on induced sputum analysis has gained popularity. However, performing induced sputum is intensive labor and limited to some expert centers.
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