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Articles by Marek Mlodzik
The Wnt co-receptor Arrow-LRP5/6 is required for planar cell polarity establishment in Drosophila
Abstract Wnt-signaling, via β−catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow/arr in Drosophila, is the obligate co-receptor in Wnt/β−catenin signaling, with ligand binding to a Frizzled (Fz) family member and LRP5/6. Current models for Wnt/PCP signaling omit Arr-LRP5/6 and PCP is presumed functioning without these co-receptors. Here we show that arr-LRP5/6 is fully required in Wnt/PCP signaling.
Wg/Wnt-signaling induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interaction with IFT-A in development and cancer cells - PubMed
This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed. bioRxiv. Display options Format doi: 10.1101/2023.06.14.544986.
Wg/Wnt-signaling induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interaction with IFT-A in development and cancer cells
Abstract Wnt/Wingless (Wg) signaling is critical for many developmental patterning processes and linked to diseases, including cancer. Canonical Wnt-signaling is mediated by β-catenin, Armadillo/Arm in Drosophila transducing signal activation to a nuclear response. The IFT-A/Kinesin-2 complex is required to promote the nuclear translocation of β-catenin/Arm.
Frizzled-Induced Van Gogh Phosphorylation by CK1ε Promotes Asymmetric Localization of Core PCP Factors in Drosophila
Fz Induces Phosphorylation of Vang in S2 Cells and In Vivo Dsh-Mediated Fz Signaling Is Not Required for Vang Phosphorylation S120/122 Phosphorylation Promotes Polarized Distribution of Vang at the Cell Membrane Fz-Induced Vang Phosphorylation Is Required for Polarized Distribution and Function of Vang in PCP Dco/CK1ε Causes Phosphorylation of the Vang Intracellular N Terminus Quantitative Analysis of Pupal Wing Images and Generation of Polarity Vectors Quantitative Analysis of Cortical...
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