Margaux Saillard on Muck Rack

Margaux Saillard

As seen in: Nature, MDPI, Science Magazine
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Articles

Engineered CD4 TCR T cells with conserved high-affinity TCRs targeting NY-ESO-1 for advanced cellular therapies in cancer

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By Jumpei Matsumoto, Constantino López-Macías, Ziqiang Xu, Margaux Saillard, Mara Cenerenti, Patrick Reichenbach, Philippe Guillaume, Ziyang Su, Morteza Hafezi, Julien Schmidt, Raphael Genolet, Lise Queiroz, Julien Racle, Jean Villard
| Science Magazine
Abstract While cancer immunotherapy has primarily focused on CD8 T cells, CD4 T cells are increasingly recognized for their role in antitumor immunity. The HLA-DRB3*02:02 allele is found in 50% of Caucasians. In this study, we screened HLA-DRB3*02:02 patients with melanoma for tumor-specific CD4 T cells and identified robust New York esophageal squamous cell carcinoma 1 (NY-ESO-1)123–137/HLA-DRB3*02:02 CD4 T cell activity in both peripheral blood and tumor tissue.
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A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor - Nature Biomedical Engineering

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By Margaux Saillard, George Coukos
| Nature
Abstract Vectors that facilitate the engineering of T cells that can better harness endogenous immunity and overcome suppressive barriers in the tumour microenvironment would help improve the safety and efficacy of T-cell therapies for more patients.
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Vaccines

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By Pedro Eduardo Romero, Camilla Jandus, Margaux Saillard, Mara Cenerenti
| MDPI
clear search menu Search for Articles: Logical OperatorOperator Submit to Special Issue Submit Abstract to Special Issue Review for Vaccines Edit a Special Issue Journal Browser ► ▼ Journal Browser Need Help? Support Find support for a specific problem in the support section of our website. Get Support Feedback Please let us know what you think of our products and services. Give Feedback Information Visit our dedicated information section to learn more about MDPI.
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