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Antenatal N-acetylcysteine supplementation in pregnant women with impending preterm birth: a prospective randomized placebo-controlled trial
Abstract Depletion of glutathione (GSH) stores is associated with preterm birth and is not corrected by neonatal supplementation with N-acetylcysteine (NAC), a GSH precursor. Whether antenatal NAC would do so, remains unknown. In a pilot, randomized, single-blinded trial (NCT03596125), women pregnant with singletons at—either severe or moderate—risk for impending preterm birth, received either N-acetylcysteine (n = 20) or placebo (n = 19).
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