Mari Bonse on Muck Rack

Mari Bonse

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Articles

Retromer promotes the lysosomal turnover of mtDNA

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By Siyi Chen, Tasneem Qaqorh, Elina Karimullina, Parisa Kakanj, Mari Bonse, Aylin Gokmen, Felix Gaedke, Elisabeth Vogelsang, Astrid Schauss, Andreas Wodarz, David Pla-Martín, Arya Kshirsagar, Ayesha Sen, Belén Mollá
| Science Magazine Verified
Abstract Mitochondrial DNA (mtDNA) is exposed to multiple insults produced by normal cellular function. Upon mtDNA replication stress, the mitochondrial genome transfers to endosomes for degradation. Using proximity biotinylation, we found that mtDNA stress leads to the rewiring of the mitochondrial proximity proteome, increasing mitochondria’s association with lysosomal and vesicle-related proteins.
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Lysosomal uptake of mtDNA mitigates heteroplasmy

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By Parisa Kakanj, Mari Bonse, Aylin Gokmen, Felix Gaedke
| biorxiv.org
Abstract Mitochondrial DNA is exposed to multiple insults produced by normal cellular function. Upon mtDNA replication stress the mitochondrial genome transfers to endosomes where it is degraded. Here, using proximity proteomics we found that mtDNA replication stress leads to the rewiring of the mitochondrial proximity proteome, increasing mitochondria association with lysosomal and vesicle-associated proteins, such as the GTPase RAB10 and the retromer.
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