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Maria Chiara Barbera on Muck Rack

Maria Chiara Barbera

As seen in: Nature
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Articles

Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses - Nature Communications

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By Maria Chiara Barbera, Luca Guarrera, Giada Andrea Cassanmagnago, Margherita Romeo, Edward V. Generozov, Rick Jansen, Brenda WJH Penninx, Ildus Ahmetov, Arianna Vallerga, Sarah Natalia Mapelli, Rosanna Piccirillo
| Nature Verified
Abstract Intensive efforts have been made to identify features that could serve as biomarkers of aging. Yet, drug-based interventions aimed at lessening the detrimental effects of getting older are lacking. This is largely attributable to tissue-specificity, sex-related differences, and to the difficulty of identifying actionable targets, which continues to pose a significant challenge.
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Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment | Cell Death & Disease

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By Michele Retini, Alexander Chernorudskiy, Marco Gobbi, Luca Guarrera, Michele Mari, Mario Salmona, Giovanni Bottegoni, Massimo Broggini, Maria Chiara Barbera, Orazio Cantoni
| Nature Verified
Abstract Cancer cells adapt to harsh environmental conditions by inducing the Unfolded Protein Response (UPR), of which ERO1A is a mediator. ERO1A aids protein folding by acting as a protein disulfide oxidase, and under cancer-related hypoxia conditions, it favors the folding of angiogenic VEGFA, leading tumor cells to thrive and spread. The upregulation of ERO1A in cancer cells, oppositely to the dispensability of ERO1A activity in healthy cells, renders ERO1A a perfect target for cancer therapy.
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