Maria Cleofé Zaragoza

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3. Discussion This work is the first to study indicators of autonomic dysfunction through variables related to the vasoconstriction/vasodilation process, also considering the subjective symptomatology of ME/CFS patients. The main outcome of this study is the association of circulating ET-1 levels with the self-reported frequency/severity of autonomic symptoms and WT-related variables, which suggests a potential role of endothelial dysfunction in ME/CFS [19].

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients frequently show autonomic symptoms which may be associated with a hypothalamic dysfunction. This study aimed to explore circadian rhythm patterns in rest and activity and distal skin temperature (DST) and their association with self-reported outcome measures, in CFS/ME patients and healthy controls at two different times of year.