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Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model

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By Johannes Hartig, Maximilian Friedrich, Maria Noel Gruber, Sawako Tabuchi, Robert Peach, Dennis W. Doll, Tobias Petschner, Susanne Knorr, Jens Volkmann, Philip Tovote, Chi Wang Ip, Jérémy Signoret-Genest, Hamidreza Alimohammadi, Max Leuschner, Nina Schöneberg, Amélie Neumann
| Nature Verified
Abstract Postural and locomotor dysfunction represent axial symptoms of Parkinson’s disease (PD), which remain poorly treated by medication and deep brain stimulation. Whilst non-invasive neuromodulation of the vestibular system via the vestibular nucleus complex (VNC) offers a novel therapeutic avenue, the underlying circuits are still poorly characterized.
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