Maria Park

1 INTRODUCTION Biodiversity supports the cycling of energy, nutrients and water through ecosystems (Schuldt et al., 2018; Tilman et al., 2014). Climate change, habitat loss and a suite of compounding factors are causing rapid declines in biodiversity (Bellard et al., 2012; Isbell et al., 2023; Segan et al., 2016). Informed stewardship of landscapes can sustain ecosystems under increasingly extreme environments (Hong et al., 2022; Wright et al., 2017).

1 Introduction While natural killer (NK) cells play a key role in immunity against cancer and viral infections, loss of NK cell functional activity has often been observed in pathological conditions in both mice and humans [1-12]. Little is known about NK cell dysfunction, precluding the development of therapeutic interventions. Mechanistic investigations have also been challenging due to the lack of reliable surface markers that identify bona fide dysfunctional NK cells.