Maria Scala

ABSTRACT Developing greener synthetic methodologies requires replacing hazardous reagents with more sustainable alternatives. In solid-phase peptide synthesis (SPPS), piperidine is the standard base for Fmoc group removal, but its toxicity, environmental concerns, and regulatory restrictions have prompted the search for safer substitutes. This study evaluates various green bases based on their GSK greenness score and chemical–physical properties similar to piperidine.

Supporting Information Filename Description epd220234-sup-0001-Test_Yourself_Answers.docxWord 2007 document , 15 KB Data S1. epd220234-sup-0002-FigureS1.zipZip archive, 792.3 KB Figure S1. REFERENCES 1, , , , , , et al. The long-term surgical outcomes of low-grade epilepsy-associated neuroepithelial tumors. Epilepsia Open. 2022; 7: 697–709. 2, , , , , , et al. Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: a retrospective nationwide Italian study. Epilepsia.

1. Introduction Influenza A virus (IAV) is an extremely infectious pathogen endowed with zoonotic potential and represents one of the leading causes of morbidity and mortality worldwide [1,2]. Over the decades, it has triggered several pandemics, causing major public health problems as well as severe economic losses [3,4]. Flu therapy is based on vaccine prevention and antiviral drug treatment. However, vaccines have several limitations.