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Maria T. Barrús on Muck Rack

Maria T. Barrús

As seen in: Journal of Pharmacology and Experimental Therapeutics
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Articles

The Melatonin Derivative ITH13001 Prevents Hypertension and Cardiovascular Alterations in Angiotensin II-Infused mice

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By Raquel Hernanz, Marta Martínez-Casales, Zoe González-Carnicero, Maria T. Barrús
| Journal of Pharmacology and Experimental Therapeutics
Abstract Inflammatory mechanisms and oxidative stress seem to contribute to the pathogenesis of hypertension. ITH13001 is a melatonin-phenyl-acrylate hybrid that moderately induces the antioxidant transcription factor Nrf2 and has a potent oxidant scavenging effect compared to other derivatives of its family. Herein, we investigated the effect of ITH13001 on hypertension and the associated cardiovascular alterations.
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The Melatonin Derivative ITH13001 Prevents Hypertension and Cardiovascular Alterations in Angiotensin II-Infused Mice

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By Marta Martínez-Casales, Raquel Hernanz, Zoe González-Carnicero, Maria T. Barrús
| Journal of Pharmacology and Experimental Therapeutics
Received March 29, 2023. Accepted November 9, 2023. ↵1 M.M.-C. and R.H. contributed equally to this work as first authors. ↵2 R.H. and M.J.A. contributed equally to this work as senior authors.
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