Mariam Fokra on Muck Rack

Mariam Fokra

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Articles

Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth

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By Dzmitry Mukha, Technion City, Cellular Oncogenesis, Mariam Fokra
| Cell Metabolism Verified
The folic acid cycle mediates the transfer of one-carbon (1C) units to support nucleotide biosynthesis. While the importance of serine as a mitochondrial and cytosolic donor of folate-mediated 1C units in cancer cells has been thoroughly investigated, a potential role of glycine oxidation remains unclear. We developed an approach for quantifying mitochondrial glycine cleavage system (GCS) flux by combining stable and radioactive isotope tracing with computational flux decomposition.
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