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Marianne Schwartz

As seen in: The New England Journal of Medicine, Science Magazine
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Articles by Marianne Schwartz

Recombination of Human Mitochondrial DNA

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By Marianne Schwartz, Timothy Brown, Yevgenya Kraytsberg, Konstantin Ebralidse
| Science Magazine Verified
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Paternal Inheritance of Mitochondrial DNA

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By John Vissing, Marianne Schwartz
| The New England Journal of Medicine Verified
Mammalian mitochondrial DNA (mtDNA) is thought to be strictly maternally inherited.1,2 Sperm mitochondria disappear in early embryogenesis by selective destruction, inactivation, or simple dilution by the vast surplus of oocyte mitochondria.3 Very small amounts of paternally inherited mtDNA have been detected by the polymerase chain reaction (PCR) in mice after several generations of interspecific backcrosses.4 Studies of such hybrids and of mouse oocytes microinjected with sperm support the...
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