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Marie-Pierre Bareille

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Articles

Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion

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By Adrien Robin, Nastassia Navasiolava, Audrey Bergouignan, Claire Laurens, Lucas Frassin, Chantal Simon, Anne Pavy-Le Traon, Marc Kermorgant, Laurence Vico, Peter R. Fernandez, Peter Fernández, Marie-Thérèse Linossier, Angele Chopard, Michael J. Tipton, Anne Tessier, Valerie Moal, David Green, Alexander Chouker, Dominique Moser, Pierre Denise, Elisabeth Rosnet, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Inês Antunes, Angelique Van Ombergen, Marc-Antoine Custaud, Dominique Larrouy, Isabelle de Glisezinski, Isabelle Harant-Farrugia, Guillaume Py, Hervé Normand, Rebecca Billette de Villemeur
| Nature Verified
Abstract Exposure to microgravity is marked by enhanced physical inactivity, reduced gravitational loading and fluid shifts. These characteristics provide a unique model for medical research. Dry immersion is used as a ground-based model to simulate and investigate some of the physiological effects of microgravity experienced by astronauts (body fluid shifts, lack of mechanical support, unloading of the musculoskeletal system and hypokinesia).
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Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies - npj Microgravity

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By Dominique Moser, Angelique Van Ombergen, Matthias Feuerecker, Christopher Dächert, Sandra Matzel, Adrien Robin, Nastassia Navasiolava, Marc-Antoine Custaud, Alexander Chouker, Marie-Pierre Bareille, Marion Hoerl, Federico D´Amico
| Nature Verified
Abstract Microgravity strongly affects human physiology during spaceflight. Biological sex has not yet been sufficiently considered as a variable for spaceflight deconditioning. The VivalDI studies investigated physiological systems affected by 5-days dry immersion (DI) in females and males, with a focus on immune changes in this report. In both sexes proportions of peripheral granulocytes and NK cells were elevated during DI and T-cell numbers were reduced.
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