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Marina Barba-Aliaga on Muck Rack

Marina Barba-Aliaga

As seen in: BioRxiv
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Articles

eIF5A controls mitoprotein import by relieving ribosome stalling at the TIM50 translocase mRNA

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By Vanessa Bernal, Brian M. Zid, Marina Barba-Aliaga, Cynthia Rong
| BioRxiv
Abstract The efficient import of nuclear-encoded proteins into mitochondria is crucial for proper mitochondrial function. The conserved translation factor eIF5A binds ribosomes to alleviate ribosome stalling at sequences encoding polyprolines. eIF5A impacts mitochondrial function across a variety of species although the precise molecular mechanism remains unclear. We found that eIF5A depletion in yeast drives reduced translation and levels of TCA cycle and oxidative phosphorylation proteins.
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