Marine A. Barnabé

1 INTRODUCTION Equine laminitis is a common and potentially devastating condition with various aetiologies, including endocrinopathies, sepsis, and excessive weight-bearing on one limb.

1 INTRODUCTION Equine endocrinopathic laminitis is a common, painful and potentially devastating condition that can affect horses, ponies and donkeys. Although multiple risk factors are recognised, insulin and adiponectin concentrations are currently the most important predictors of endocrinopathic laminitis risk.1, 2 These two hormones are commonly measured in equids, using either serum or plasma obtained via jugular venipuncture.

1 INTRODUCTION Insulin dysregulation (ID), the key feature of equine metabolic syndrome (EMS), may manifest as tissue insulin resistance (IR), basal hyperinsulinaemia, or an excessive insulin response to hydrolysable carbohydrates.1 Previous studies have shown that continuous infusion of insulin via a euglycaemic–hyperinsulinaemic clamp (EHC) reliably causes endocrinopathic laminitis in healthy equids.2, 3 Although various histological and physiological changes associated with the actions of...