Mario A. Ostrowski

Abstract Traces of HIV-1 RNA can persist in plasma despite long-term suppressive antiretroviral therapy (ART). Some individuals develop nonsuppressible viremia (NSV), characterized by detectable HIV-1 RNA that raises concerns for virological failure, pathogenesis, and transmission. The sources of NSV remain poorly defined, in part due to limited tools to characterize plasma HIV-1 RNA.

Abstract The human immune system is intrinsically variable and remarkably diverse across a population. The immune response to antigens is driven by a complex interplay of time-dependent interdependencies across components of the immune system. After repeated vaccination, the humoral and cellular arms of the immune response display highly heterogeneous dynamics, further complicating the attribution of a phenotypic outcome to specific immune system components.

Correction to: Scientific Reports https://doi.org/10.1038/s41598-018-19298-x, published online 16 January 2018 The Acknowledgements section in this Article is incomplete. “We thank M. Mylvaganam and J. La of C.A.L.’s lab for convallatoxin derivatives; S. Mujib for assistance in preparing HIV-infected PBMCs for culture; A. Y.Q. Mao for AKT-1 transfections; T. Hoque and S.-K. Whyte of R. Bendayan’s lab for BMVEC cDNAs and L. Ming for THP-1 cDNAs and NKA shRNA supernatants; A.