Marion Barbazanges

Abstract Click to copy section linkSection link copied! The selective hydrogenation of quinolines is a valuable transformation for accessing functionalized N-heterocycles, but achieving control over the degree of reduction under mild and sustainable conditions remains challenging. Herein, we report the transfer hydrogenation of quinoline using 1 equiv of ammonia–borane (NH3BH3) at room temperature, catalyzed by two well-defined cobalt hydride complexes: HCo(PMe3)4 and H3Co(PPh3)3.

Abstract Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallization has been hampered by the often-limiting resolution and throughput of cryogenic electron microscopy (cryo-EM).