Marion Bardou

Abstract Three-dimensional (3D) genome folding has a fundamental role in the regulation of developmental genes by facilitating or constraining chromatin interactions between cis-regulatory elements (CREs). Polycomb response elements (PREs) are a specific kind of CRE involved in the memory of transcriptional states in Drosophila melanogaster.

Abstract The three-dimensional (3D) nuclear organization of chromatin in eukaryotes plays a crucial role in gene regulation, DNA replication, and DNA damage repair. While genome-wide ensemble methods have enhanced our understanding of chromatin organization, they lack the ability to capture single-cell heterogeneity and preserve spatial information. To overcome these limitations, a new family of imaging-based methods has emerged, giving rise to the field of spatial genomics.

Correction to: Nature Photonics https://doi.org/10.1038/s41566-020-00749-9, published online 25 January 2021. In the version of this Article originally published, Marion Bardou was mistakenly affiliated with the Centre de Biologie Structurale, CNRS, INSERM, Université de Montpellier, Montpellier, France; the affiliation has now been corrected to Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d’Orsay, Orsay, France.