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Marisa D Ruehle on Muck Rack

Marisa D Ruehle

As seen in: BioRxiv, Journal of Cell Biology
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Articles

The Structure of Cilium Inner Junctions Revealed by Electron Cryo-tomography

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By Sam Li, Jose-Jesus Fernández, Marisa D Ruehle, Rachel Howard-Till
| BioRxiv
Abstract The cilium is a microtubule-based organelle critical for many cellular functions. Its assembly initiates at a basal body and continues as an axoneme that projects out of the cell to form a functional cilium. This assembly process is tightly regulated. However, our knowledge of the molecular architecture and the mechanism of assembly is limited.
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Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections

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By Marisa D Ruehle, Sam Li, David Agard
| Journal of Cell Biology
Basal bodies (BBs) are conserved eukaryotic structures that organize cilia. They are comprised of nine, cylindrically arranged, triplet microtubules (TMTs) connected to each other by inter-TMT linkages which stabilize the structure.
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Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections

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By Sam Li, David Agard, Chad G. Pearson, Marisa D Ruehle
| BioRxiv
Abstract Basal bodies (BBs) are conserved eukaryotic structures that organize motile and primary cilia. The BB is comprised of nine, cylindrically arranged, triplet microtubules (TMTs) that are connected to each other by inter-TMT linkages which maintain BB structure. During ciliary beating, forces transmitted to the BB must be resisted to prevent BB disassembly. Poc1 is a conserved BB protein important for BBs to resist ciliary forces.
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