Marius Wilhelm Baeken

1 INTRODUCTION Maintaining proteostasis, particularly under cellular stress conditions that promote protein misfolding or degradation, is crucial for a functional proteome. Accordingly, sophisticated protein quality control mechanisms have evolved, and eukaryotic cells govern the disposal of dysfunctional proteins via the ubiquitin–proteasome system and the autophagosome–lysosome pathway. Consequently, it is essential to specifically select such proteins that need to be degraded.