Marja K. Puurunen on Muck Rack

Marja K. Puurunen

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Articles

Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial - Nature Metabolism

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By Jerry Vockley, Neal Sondheimer, Marja K. Puurunen, Dorothy K. Grange, Cary O. Harding, Hope Northrup, William Denney, Caroline B. Kurtz
| Nature Verified
Abstract Despite available treatment options, many patients with phenylketonuria (PKU) cannot achieve target plasma phenylalanine (Phe) levels1. We previously modified Escherichia coli Nissle 1917 to metabolize Phe in the gut after oral administration (SYNB1618) and designed a second strain (SYNB1934) with enhanced activity of phenylalanine ammonia lyase2,3.
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An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

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By Caroline B. Kurtz, Yves A. Millet, Marja K. Puurunen, Mylène Perreault
| Science Magazine Verified
Research ArticleMetabolism Caroline B. Kurtz1,*, Yves A. Millet1,†, Marja K. Puurunen1, Mylène Perreault1, Mark R. Charbonneau1, Vincent M. Isabella1, Jonathan W. Kotula1,‡, Eugene Antipov1, Yossi Dagon1, William S. Denney2, David A. Wagner3, Kip A. West1, Andrew J. Degar4, Aoife M. Brennan1 and Paul F. Miller1 1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA. 2Human Predictions LLC, 649 Massachusetts Avenue Suite 6, Cambridge, MA 02139, USA.
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