Research Articles Mark A. Guinter, Susan M. Gapstur, Marjorie L. McCullough, W. Dana Flanders, Ying Wang, Erika Rees-Punia, Kassandra I. Alcaraz, Michael N. Pollak and Peter T. Campbell DOI: 10.1158/1055-9965.EPI-19-1382 Published May 2020 Abstract Background: Energy balance–related factors, such as body mass index (BMI), diet, and physical activity, may influence colorectal cancer etiology through interconnected metabolic pathways, but their combined influence is less clear.