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Mark Bailey

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The distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana resolve the Central Dogma’s information flow | Genome Biology | Full Text

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By Rothamsted Research, Ziming Zhong, Mark Bailey, Yong-In Kim, Nazanin P. Afsharyan, Xiaowei Li, Chelsea Rundle, Andrew Behrens, Danny D. Nedialkova, Gancho T Slavov, Keywan Hassani-Pak, Kathryn S. Lilley, Frederica L. Theodoulou, Richard Mott, Briony Parker, Louise Arathoon
| Genome Biology Verified
It is a remarkable fact that although most genes are encoded only once in the nuclear genome, their constitutive expression levels vary by orders of magnitude [24]. In the Arabidopsis thaliana rosette leaves studied here, the most highly expressed genes exceed the median level by over 1,000-fold for mRNA and over 500-fold for protein. The key questions address these levels’ reproducibility, and how they are set and maintained.
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