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Articles by Mark Dorr
Reprogramming of bacterial virulence by lysine acetylation
Abstract Gram-negative bacteria use a plethora of virulence factors to infect eukaryotic cells. CE-clan protease-related virulence factors were reported to act as deubiquitinases/ubiquitin-like specific proteases. Some have an additional acetyl-transferase activity. The molecular mechanisms underlying this dual activity and the physiological consequences are only marginally understood.
AcuB senses cellular energy charge to coordinate acetyl-CoA synthesis in bacteria
Abstract Bacteria adjust their metabolism to the cellular energy state. AMP-forming acetyl-CoA-synthetase AcsA generates acetyl-CoA from acetate, ATP and CoA. In Bacilli, including Bacillus subtilis and Geobacillus stearothermophilus, AcsA is reversely transcribed upstream of the acu-operon encoding for the proteins AcuA, AcuB and AcuC. Lysine-acetyltransferase AcuA uses acetyl-CoA to acetylate and inactivate AcsA, while AcuC re-activates AcsA activity by deacetylation.
Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis - Nature Communications
Abstract Acute pancreatitis (AP) is characterised by self-digestion of the pancreas by its own proteases. This pathophysiological initiating event in AP occurs inside pancreatic acinar cells where intrapancreatic trypsinogen becomes prematurely activated by cathepsin B (CTSB), and induces the digestive protease cascade, while cathepsin L (CTSL) degrades trypsin and trypsinogen and therefore prevents the development of AP.
Another Voice: Bring fairness and transparency to short-term rentals
Let us be the first to say that New York State’s tourism industry needs short-term rentals (like Airbnb and VRBO) to be successful. A record 303 million travelers visited the great state of New York in 2023, and they need places to stay. But for New York’s tourism industry to be successful and sustainable, we need a better system to manage the growth of the short-term rental industry. Short-term lodging accommodations outside of New York City accounted for more than $1 billion in revenue in 2023.
Front Cover: Product Distribution of Steady-State and Pulsed Electrochemical Regeneration of 1,4‐NADH and Integration with Enzymatic Reaction (ChemistryOpen 8/2024) - Al‐Shaibani - 2024 - ChemistryOpen - Wiley Online Library
Mohammed Ali Saif Al-Shaibani Electrochemical Energy Conversion, Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstraße 1, 39106 Magdeburg, Germany Search for more papers by this author
Product Distribution of Steady-State and Pulsed Electrochemical Regeneration of 1,4‐NADH and Integration with Enzymatic Reaction
Introduction Oxidoreductases are an important class of enzymes1 that catalyze oxidative or reductive biotransformations, more specifically they transfer electron or redox equivalents, from a donor molecule to the corresponding acceptor molecule.2 The enzymatically catalyzed redox reactions have thus been the focus of scientific interest due to their potential in a variety of industrial applications.3 Despite this, they have not yet been widely used on an industrial scale due to limitations...
Data‐Driven Protein Engineering for Improving Catalytic Activity and Selectivity
Introduction Protein engineering is essential to improve the catalytic function of enzymes including substrate scope, catalytic activity and selectivity to produce pharmaceuticals, flavors and fragrances, other fine and specialty chemicals as well as biofuels to establish green chemistry processes.1 Currently, two classical approaches for protein engineering, directed evolution and rational design, are mainly employed to design enzyme variants with increased activity, broader substrate scope...
Data‐Driven Protein Engineering for Improving Catalytic Activity and Selectivity
Protein engineering is essential for altering the substrate scope, catalytic activity and selectivity of enzymes for applications in biocatalysis. However, traditional approaches, such as directed evolution and rational design, encounter the challenge in dealing with the experimental screening process of a large protein mutation space.
A Systematic Analysis of the Substrate Scope of (S)- and (R)-Selective Amine Transaminases
Amine transaminases (ATAs) emerged as an important group of biocatalysts for the synthesis of optically pure amines over the past few decades. In the same way, the amount of available data for ATA-catalyzed reactions increased significantly, forming the basis for a deeper understanding of this versatile group of enzymes.
Mark Dorr | New York State Hospitality and Tourism Association
Mark Dorr | New York State Hospitality and Tourism Association By: Daily Record Staff September 9, 2016 0 Mark Dorr has been named president of the New York State Hospitality and Tourism Association (NYSH&TA), a not-for-profit trade organization that represents businesses and individuals in the lodging and attraction industry in the state. Prior to this promotion, Dorr served as vice-president and communications manager for the organization.
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