Mark Ellie Alonzo on Muck Rack

Mark Ellie Alonzo

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Articles

Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors - Nature Communications

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By Fotis Nikolos, Xen Ping Hoi, Mark Ellie Alonzo, Qianxing Mo, Hideki Furuya, Dan Theodorescu, Charles Rosser, Andrea B. Apolo, Keith Chan
| Nature Verified
Abstract Chemoimmunotherapy has recently failed to demonstrate significant clinical benefit in advanced bladder cancer patients; and the mechanism(s) underlying such suboptimal response remain elusive. To date, most studies have focused on tumor-intrinsic properties that render them “immune-excluded”. Here, we explore an alternative, drug-induced mechanism that impedes therapeutic response via disrupting the onset of immunogenic cell death.
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