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Articles by Mark Fleming
Long-read transcriptome analysis using IsoRanker for identifying pathogenic variants in Mendelian conditions
Keywords long-read transcript IsoRanker Mendelian HARS1 rare disease variant interpretation splicing RNA transcriptomics functional genomics Get full text access Log in, subscribe or purchase for full access. References 1. Yang, Y. ∙ Muzny, D.M. ∙ Reid, J.G. ... Clinical whole-exome sequencing for the diagnosis of mendelian disorders N. Engl. J. Med. 2013; 369:1502-1511 2. Kurosaki, T. ∙ Maquat, L.E. Nonsense-mediated mRNA decay in humans at a glance J. Cell Sci. 2016; 129:461-467 3. Wang, G.-S.
An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary The molecule heme has important functions in oxygen transport, as a cofactor for enzymes, and as a sensor. It must be available as needed, but excessive synthesis can cause the accumulation of toxic precursors or depletion of iron, so its production is tightly controlled.
True-Positive 18F-Flotufolastat Lesions in Patients with Prostate Cancer Recurrence with Baseline-Negative Conventional Imaging: Results from the Prospective, Phase 3, Multicenter SPOTLIGHT Study
18F-flotufolastat PSMA rhPSMA prostate cancer biochemical recurrence To effectively manage recurrent prostate cancer, it is essential to have accurate imaging techniques since the presence, volume, and distribution of disease will determine therapeutic choices (1).
True-Positive 18F-Flotufolastat Lesions in Patients with Prostate Cancer Recurrence with Baseline-Negative Conventional Imaging: Results from the Prospective, Phase 3, Multicenter SPOTLIGHT Study
18F-flotufolastat PSMA rhPSMA prostate cancer biochemical recurrence To effectively manage recurrent prostate cancer, it is essential to have accurate imaging techniques since the presence, volume, and distribution of disease will determine therapeutic choices (1).
Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis
Research Article CELL BIOLOGY Adam G. Maynard https://orcid.org/0000-0001-6630-0071, Nancy K. Pohl https://orcid.org/0000-0002-9173-3247, [...] , Annabel P. Mueller https://orcid.org/0009-0006-7213-4069, Boryana Petrova https://orcid.org/0000-0001-9996-9353, [...] , Alan Y. L. Wong https://orcid.org/0000-0001-5908-6820, Peng Wang https://orcid.org/0000-0001-8118-4929, Andrew J. Culhane, Jeannette R. Brook, Leah M. Hirsch, [...] , Ngoc Hoang, Orville O.
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