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Mark Giembycz on Muck Rack

Mark Giembycz

Calgary
As seen in: Journal of Pharmacology and Experimental Therapeutics
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Articles

The "β-Blocker" Carvedilol and Related Aryloxypropanolamines Promote ERK1/2 Phosphorylation in HEK293 Cells with KA Values Distinct from their Equilibrium Dissociation Constants as β2-Adrenoceptor Antagonists: Evidence for Functional Affinity

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By Omar Hamed, Varuna Jayasinghe, Mark Giembycz
| Journal of Pharmacology and Experimental Therapeutics
Abstract The determination of affinity by using functional assays is important in drug discovery because it provides a more relevant estimate of the strength of interaction of a ligand to its cognate receptor than radioligand binding. However, empirical evidence for, so-called, "functional affinity" is limited.
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The β-Blocker Carvedilol and Related Aryloxypropanolamines Promote ERK1/2 Phosphorylation in HEK293 Cells with KA Values Distinct From Their Equilibrium Dissociation Constants as β2-Adrenoceptor Antagonists: Evidence for Functional Affinity

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By Omar Hamed, Varuna Jayasinghe, Mark Giembycz
| Journal of Pharmacology and Experimental Therapeutics
Footnotes Received September 6, 2023. Accepted November 13, 2023. This study was supported the Canadian Institutes for Health Research (Project Grants PJT 152904 and PJT 185848) and by a Natural Sciences and Engineering Research Council Discovery Grant (RGPIN-2018-04312). O.H. was a recipient of a studentship awarded by The Lung Association of Alberta & NWT.
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Prostanoid receptors in GtoPdb v.2023.1

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By Akos Heinemann, Robert Jones, Lucie Clapp, Mark Giembycz
| paperity.org
IUPHAR/BPS Guide to Pharmacology CITE, Apr 2023 Lucie Clapp, Mark Giembycz, Akos Heinemann, Robert L. Jones, Shuh Narumiya, Xavier Norel, Yukihiko Sugimoto, David F. Woodward, Chengcan Yao. , IUPHAR/BPS Guide to Pharmacology CITE, 2023, Volume 2023, Issue 1,
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