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Articles by Mark Habgood
Gestational Valproate Exposure Induces Tissue‐Specific Transcriptomic Changes in the Neonatal Brain and Choroid Plexus in a Rat Model of Epilepsy, GAERS
ABC ATP (adenosine triphosphate)–binding cassette CPM counts per million CSF cerebrospinal fluid DMEs drug-metabolising enzymes E embryonic day GAERS Genetic Absence Epilepsy Rat from Strasbourg P postnatal day SD standard deviation SLCs solute carriers VPA valproate 1 Introduction It has long been observed that valproate, an effective antiseizure medication (Tomson et al.
Effects of co‐administration of lamotrigine on valproate transfer across the placenta and its brain entry in developing Genetic Absence Epilepsy Rats from Strasbourg (GAERS)
ASM antiseizure medications CNS central nervous system CSF cerebrospinal fluid DPM disintegration per minute E embryonic Day GAERS Genetic Absence Epilepsy Rat from Strasbourg i.p. intraperitoneal i.v. intravenous LTG lamotrigine P postnatal day SD standard deviation VPA valproate 1 INTRODUCTION Epilepsy is a group of chronic neurological diseases that affects over 74 million people globally with a cumulative incidence of 67.77 per 100,000 per year, making it one of the most common...
Extent of foetal exposure to maternal elexacaftor/tezacaftor/ivacaftor during pregnancy
AB/PAS Alcian blue/periodic acid-schiff CF cystic fibrosis DEG differentially expressed gene ETI elexacaftor/tezacaftor/ivacaftor F508del Phe508del variant GO gene ontology H&E haematoxylin and eosin Log2FC Log2 fold change RNA-seq RNA sequencing 1 INTRODUCTION Breakthroughs in the development of therapies that target the underlying cause of cystic fibrosis (CF) were made possible by the discovery that CF is caused by pathogenic variants of the cystic fibrosis transmembrane conductance...
F1000Research Article: Entry of antiepileptic drugs (valproate and lamotrigine) into the developing rat brain.
Research Article Revised [version 2; peer review: 2 approved, 1 approved with reservations] Samuel J. Toll https://orcid.org/0000-0003-0323-9589 1*, Fiona Qiu https://orcid.org/0000-0003-0642-1116 1*, Yifan Huang https://orcid.org/0000-0003-1060-3668 1, [...] Mark D. Habgood1, Katarzyna M. Dziegielewska https://orcid.org/0000-0002-0070-904X 1, Shuai Nie2, https://orcid.org/0000-0001-6660-7639 1 Samuel J.
Research Check: does paracetamol in pregnancy cause child behavioural problems?
Paracetamol is widely used in all stages of pregnancy to reduce a high temperature and relieve pain. It should be taken only when needed, but is generally considered safe for the baby.
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